Selective Assembly of TRPC Channels in the Rat Retina during Photoreceptor Degeneration.

ABSTRACT: Transient receptor potential canonical (TRPC) channels are calcium channels with diverse expression profiles and physiological implications in the retina. Neurons and glial cells of rat retinas with photoreceptor degeneration caused by retinitis pigmentosa (RP) exhibit basal calcium levels that are above those detected in healthy retinas. Inner retinal cells are the last to degenerate and are responsible for maintaining the activity of the visual cortex, even after complete loss of photoreceptors. We considered the possibility that TRPC1 and TRPC5 channels might be associated with both the high calcium levels and the delay in inner retinal degeneration. TRPC1 is known to mediate protective effects in neurodegenerative processes while TRPC5 promotes cell death. In order to comprehend the im

SUBMITTER: Caminos E 

PROVIDER: S-EPMC11242081 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature