Systemic Inflammation Disrupts Circadian Rhythms and Diurnal Neuroimmune Dynamics.

ABSTRACT: Circadian rhythms regulate physiological processes in approximately 24 h cycles, and their disruption is associated with various diseases. Inflammation may perturb circadian rhythms, though these interactions remain unclear. This study examined whether systemic inflammation induced by an intraperitoneal injection of lipopolysaccharide (LPS) could alter central and peripheral circadian rhythms and diurnal neuroimmune dynamics. Mice were randomly assigned to two groups: the saline control group and the LPS group. The diurnal expression of circadian clock genes and inflammatory cytokines were measured in the hypothalamus, hippocampus, and liver. Diurnal dynamic behaviors of microglia were also assessed. Our results revealed that the LPS perturbed circadian gene oscillations in the hypothalamu

SUBMITTER: Cheng WY 

PROVIDER: S-EPMC11242289 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature