Are adverse events higher among patients with acute optic neuritis prescribed glucocorticoids? A retrospective, longitudinal cohort study.

ABSTRACT:

Objective

Optic neuritis (ON) is an acute focal inflammation of the optic nerve routinely treated with glucocorticoids. We aimed to compare adverse events (AE) among glucocorticoid-treated and untreated patients in the real world to guide clinical decision making about treatment tradeoffs.

Design

Retrospective, longitudinal cohort study.

Setting

Claims study from a large, private insurer in the USA (2005-2019).

Participants

Adults≥18 years old with ≥1 ICD9/10 ON diagnosis with an evaluation/management visit code, and ≥6 months continuous enrolment prior to and following ON diagnosis.

Intervention

Glucocorticoid prescription exposure.

Primary and secondary outcome measures

Primary outcome was any AE within 90 days of glucocorticoid prescription. Se

SUBMITTER: De Lott LB 

PROVIDER: S-EPMC11243139 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature