Isovaleryl Sucrose Esters from Atractylodes japonica and Their Cytotoxic Activity.

ABSTRACT: Cancer represents one of the most significant health challenges currently facing humanity, and plant-derived antitumour drugs represent a prominent class of anticancer medications in clinical practice. Isovaleryl sucrose esters, which are natural constituents, have been identified as having potential antitumour effects. However, the mechanism of action remains unclear. In this study, 12 isovaleryl sucrose ester components, including five new (1-5) and seven known compounds (6-12), were isolated from the roots of Atractylodes japonica. The structures of the compounds were elucidated using 1D and 2D-NMR spectroscopy, complemented by HR-ESI-MS mass spectrometry. The cytotoxic activities of all the compounds against human colon cancer cells (HCT-116) and huma

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11243297 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature