Development of Focused Ultrasound-Assisted Nanoplexes for RNA Delivery.

ABSTRACT: RNA-based therapeutics, including siRNA, have obtained recognition in recent years due to their potential to treat various chronic and rare diseases. However, there are still limitations to lipid-based drug delivery systems in the clinical use of RNA therapeutics due to the need for optimization in the design and the preparation process. In this study, we propose adaptive focused ultrasound (AFU) as a drug loading technique to protect RNA from degradation by encapsulating small RNA in nanoliposomes, which we term nanoplexes. The AFU method is non-invasive and isothermal, as nanoplexes are produced without direct contact with any external materials while maintaining precise temperature control according to the desired settings. The controllability of sample treatments can be effectively mod

SUBMITTER: Ranjan S 

PROVIDER: S-EPMC11243722 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature