Photoacoustic lifetime oxygen imaging of radiotherapy-induced tumor reoxygenation In Vivo.

ABSTRACT:

Purpose

Early detection and diagnosis of cancer is critical for achieving positive therapeutic outcomes. Biomarkers that can provide clinicians with clues to the outcome of a given therapeutic course are highly desired. Oxygen is a small molecule that is nearly universally present in biological tissues and plays a critical role in the effectiveness of radiotherapies by reacting with DNA radicals and subsequently impairing cellular repair of double strand breaks.Techniques for measuring oxygen in biological tissues often use blood oxygen saturation to approximate the oxygen partial pressure in surrounding tissues despite the complex, nonlinear, and dynamic relationship between these two separate oxygen populations.

Methods and materials

We combined a directly oxygen-sensitive

SUBMITTER: Folz J 

PROVIDER: S-EPMC11243757 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature