Cancer histology in metastatic lymph node predicts prognosis in patients with node-positive stage IV colorectal cancer.

ABSTRACT:

Background

Appropriate prognostic indicators are required for patients with stage IV colorectal cancer (CRC). Lymph node metastasis mainly involves four histological types of CRC. Some metastatic lymph nodes (mLNs) showing cribriform carcinoma are associated with distant metastasis in patients with node-positive CRC and are correlated with recurrence and survival in stage III disease. However, the significance of mLN histology in the prognosis of patients with node-positive stage IV disease remains unclear.

Methods

We enrolled 449 consecutive patients with CRC who underwent primary tumor resection with lymph node dissection between January 2011 and November 2018. This study included 88 patients with node-positive stage IV CRC and synchronous or metachronous distant metastase

SUBMITTER: Yokoyama S 

PROVIDER: S-EPMC11243965 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature