The embodiment of the neighborhood socioeconomic environment in the architecture of the immune system.

ABSTRACT: There is growing recognition of the importance of immune health for understanding the origins of ageing-related disease and decline. Numerous studies have demonstrated consistent associations between the social determinants of health and immunosenescence (i.e. ageing of the immune system). Yet few studies have interrogated the relationship between neighborhood socioeconomic status (nSES) and biologically specific measures of immunosenescence. We used data from the US Health and Retirement Study to measure immunosenescence linked with neighborhood socioeconomic data from the National Neighborhood Data Archive to examine associations between indicators of nSES and immunosenescence. We found associations between both the ratio of terminally differentiated effector memory to naïve (EMRA:Naïve)

SUBMITTER: Noppert GA 

PROVIDER: S-EPMC11244187 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature