An Insulin-Modified pH-Responsive Nanopipette Based on Ion Current Rectification.

ABSTRACT: The properties of nanopipettes largely rely on the materials introduced onto their inner walls, which allow for a vast extension of their sensing capabilities. The challenge of simultaneously enhancing the sensitivity and selectivity of nanopipettes for pH sensing remains, hindering their practical applications. Herein, we report insulin-modified nanopipettes with excellent pH response performances, which were prepared by introducing insulin onto their inner walls via a two-step reaction involving silanization and amidation. The pH response intensity based on ion current rectification was significantly enhanced by approximately 4.29 times when utilizing insulin-modified nanopipettes compared with bare ones, demonstrating a linear response within the pH range of 2.50 to 7.80. In addition, i

SUBMITTER: Wang XF 

PROVIDER: S-EPMC11244478 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature