Host JAK-STAT activity is a target of parasitoid wasp virulence strategies.

ABSTRACT: Innate immune responses that allow hosts to survive infection depend on the action of multiple conserved signaling pathways. Pathogens and parasites in turn have evolved virulence factors to target these immune signaling pathways in an attempt to overcome host immunity. Consequently, the interactions between host immune molecules and pathogen virulence factors play an important role in determining the outcome of an infection. The immune responses of Drosophila melanogaster provide a valuable model to understand immune signaling and host-pathogen interactions. Flies are commonly infected by parasitoid wasps and mount a coordinated cellular immune response following infection. This response is characterized by the production of specialized blood cells called lamellocytes that form a tight ca

SUBMITTER: Brantley SE 

PROVIDER: S-EPMC11244843 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature