Selection for early reproduction leads to accelerated aging and extensive metabolic remodeling in <i>Drosophila melanogaster</i>.

ABSTRACT: Experimental evolution studies that feature selection on life-history characters are a proven approach for studying the evolution of aging and variation in rates of senescence. Recently, the incorporation of genomic and transcriptomic approaches into this framework has led to the identification of hundreds of genes associated with different aging patterns. However, our understanding of the specific molecular mechanisms underlying these aging patterns remains limited. Here, we incorporated extensive metabolomic profiling into this framework to generate mechanistic insights into aging patterns in Drosophila melanogaster. Specifically, we characterized metabolomic change over adult lifespan in populations of D. melanogaster where selection for early reproduction has led to an ac

SUBMITTER: Hubert DL 

PROVIDER: S-EPMC11244849 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature