Self-organizing recruitment of compensatory areas maximizes residual motor performance post-stroke.

ABSTRACT: Whereas the orderly recruitment of compensatory motor cortical areas after stroke depends on the size of the motor cortex lesion affecting arm and hand movements, the mechanisms underlying this reorganization are unknown. Here, we hypothesized that the recruitment of compensatory areas results from the motor system's goal to optimize performance given the anatomical constraints before and after the lesion. This optimization is achieved through two complementary plastic processes: a homeostatic regulation process, which maximizes information transfer in sensory-motor networks, and a reinforcement learning process, which minimizes movement error and effort. To test this hypothesis, we developed a neuro-musculoskeletal model that controls a 7-muscle planar arm via a cortical network that incl

SUBMITTER: Lee K 

PROVIDER: S-EPMC11244868 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature