APOE, Immune Factors, Sex, and Diet Interact to Shape Brain Networks in Mouse Models of Aging.

ABSTRACT: Alzheimer's disease (AD) presents complex challenges due to its multifactorial nature, poorly understood etiology, and late detection. The mechanisms through which genetic, fixed and modifiable risk factors influence susceptibility to AD are under intense investigation, yet the impact of unique risk factors on brain networks is difficult to disentangle, and their interactions remain unclear. To model multiple risk factors including APOE genotype, age, sex, diet, and immunity we leveraged mice expressing the human APOE and NOS2 genes, conferring a reduced immune response compared to mouse Nos2. Employing graph analyses of brain connectomes derived from accelerated diffusion-weighted MRI, we assessed the global and local impact of risk factors in the absence of AD pathology. Aging and a high

SUBMITTER: Winter S 

PROVIDER: S-EPMC11244909 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature