HCV- and HBV-mediated liver cancer converge on similar transcriptomic landscapes and immune profiles.

ABSTRACT: Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related deaths worldwide, and a large proportion of HCC is attributable to viral causes including hepatitis B (HBV) and C virus (HCV). The pathogenesis of viral-mediated HCC can differ between HBV and HCV, but it is unclear how much these differences influence the tumors' final molecular and immune profiles. Additionally, there are known sex differences in the molecular etiology of HCC, but sex differences have not been explored in the context of viral-mediated HCC. To determine the extent to which the viral status and sex impact the molecular and immune profiles of HCC, we performed differential expression and immune cell deconvolution analyses. We identified a large number of differentially expressed genes unique to the HBV

SUBMITTER: Borden ES 

PROVIDER: S-EPMC11244919 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature