Adult-neurogenesis allows for representational stability and flexibility in early olfactory system.

ABSTRACT: In the early olfactory system, adult-neurogenesis, a process of neuronal replacement results in the continuous reorganization of synaptic connections and network architecture throughout the animal s life. This poses a critical challenge: How does the olfactory system maintain stable representations of odors and therefore allow for stable sensory perceptions amidst this ongoing circuit instability? Utilizing a detailed spiking network model of early olfactory circuits, we uncovered dual roles for adult-neurogenesis: one that both supports representational stability to faithfully encode odor information and also one that facilitates plasticity to allow for learning and adaptation. In the main olfactory bulb, adult-neurogenesis affects neural codes in individual mitral and tufted cells but pr

SUBMITTER: Chen Z 

PROVIDER: S-EPMC11244980 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature