Sensitive detection of synthetic response to cancer immunotherapy driven by gene paralog pairs.

ABSTRACT: Emerging immunotherapies such as immune checkpoint blockade (ICB) and chimeric antigen receptor T-cell (CAR-T) therapy have revolutionized cancer treatment and have improved the survival of patients with multiple cancer types. Despite this success many patients are unresponsive to these treatments or relapse following treatment. CRISPR activation and knockout (KO) screens have been used to identify novel single gene targets that can enhance effector T cell function and promote immune cell targeting and eradication of tumors. However, cancer cells often employ multiple genes to promote an immunosuppressive pathway and thus modulating individual genes often has a limited effect. Paralogs are genes that originate from common ancestors and retain similar functions. They often have complex effe

SUBMITTER: Dong C 

PROVIDER: S-EPMC11245041 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature