Adolescent Cardiorespiratory Fitness and Risk of Cancer in Late Adulthood: Nationwide Sibling-Controlled Cohort Study.

ABSTRACT:

Objective

To investigate whether the higher risks of certain cancers associated with high cardiorespiratory fitness can be explained by increased detection and unobserved confounders.

Design

Nationwide sibling-controlled cohort study of adolescents.

Setting

Sweden.

Participants

1 124 049 men of which 477 453 were full siblings, who underwent mandatory military conscription examinations between 1972 and 1995 at a mean age of 18.3 years.

Main outcome measures

Hazard ratios (HR) and 95% confidence intervals (CI) of overall cancer diagnosis and cancer mortality, and 14 site-specific cancers (diagnosis or death), as recorded in the Swedish National Patient Register or Cause of Death Register until 31 December 2023, modelled using flexible parametric regressio

SUBMITTER: Ballin M 

PROVIDER: S-EPMC11245056 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature