No evidence for causal effects of C-reactive protein (CRP) on chronic pain conditions: a Mendelian randomization study.

ABSTRACT:

Objective

We conducted a Mendelian randomization (MR) study to examine causal associations of C-reactive protein (CRP) with (1) spinal pain; (2) extent of multisite chronic pain; and (3) chronic widespread musculoskeletal pain.

Design

Two-sample MR study.

Setting/subjects

We used summary statistics from publicly available genome-wide association studies (GWAS) conducted in multiple cohorts and biobanks. Genetic instrumental variables were taken from an exposure GWAS of CRP (n=204,402). Outcome GWASs examined spinal pain (n=1,028,947), extent of multisite chronic pain defined as the number of locations with chronic pain (n=387,649), and chronic widespread pain (n=249,843).

Methods

We examined MR evidence for causal associations using inverse-variance weighted (I

SUBMITTER: Suri P 

PROVIDER: S-EPMC11245067 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature