Integrative genomic reconstruction reveals heterogeneity in carbohydrate utilization across human gut bifidobacteria.

ABSTRACT: Bifidobacteria are among the earliest colonizers of the human gut and are widely used as probiotics for their health-promoting properties. However, individual responses to probiotic supplementation may vary with strain type(s), microbiota composition, diet, or lifestyle conditions, highlighting the need for strain-level insights into the bifidobacterial metabolism of dietary and host glycans. Here, we systematically reconstructed 68 pathways involved in the utilization of mono-, di-, oligo-, and polysaccharides by analyzing the distribution of 589 curated metabolic functional roles (catabolic enzymes, transporters, transcriptional regulators) in 3083 non-redundant cultured Bifidobacterium isolates and metagenome-assembled genomes (MAGs) of human origin. Our analysis uncovered extens

SUBMITTER: Arzamasov AA 

PROVIDER: S-EPMC11245093 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature