Molecular and cellular rhythms in excitatory and inhibitory neurons in the mouse prefrontal cortex.

ABSTRACT: Previous studies have shown that there are rhythms in gene expression in the mouse prefrontal cortex (PFC); however, the contribution of different cell types and potential variation by sex has not yet been determined. Of particular interest are excitatory pyramidal cells and inhibitory parvalbumin (PV) interneurons, as interactions between these cell types are essential for regulating the excitation/inhibition balance and controlling many of the cognitive functions regulated by the PFC. In this study, we identify cell-type specific rhythms in the translatome of PV and pyramidal cells in the mouse PFC and assess diurnal rhythms in PV cell electrophysiological properties. We find that while core molecular clock genes are conserved and synchronized between cell types, pyramidal cells have nea

SUBMITTER: Burns JN 

PROVIDER: S-EPMC11245095 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature