Robustness of mitochondrial biogenesis and respiration explain aerobic glycolysis.

ABSTRACT: A long-standing observation is that in fast-growing cells, respiration rate declines with increasing growth rate and is compensated by an increase in fermentation, despite respiration being more efficient than fermentation. This apparent preference for fermentation even in the presence of oxygen is known as aerobic glycolysis, and occurs in bacteria, yeast, and cancer cells. Considerable work has focused on understanding the potential benefits that might justify this seemingly wasteful metabolic strategy, but its mechanistic basis remains unclear. Here we show that aerobic glycolysis results from the saturation of mitochondrial respiration and the decoupling of mitochondrial biogenesis from the production of other cellular components. Respiration rate is insensitive to acute perturbations

SUBMITTER: Arunachalam E 

PROVIDER: S-EPMC11245115 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature