Causal relationship between inflammatory markers and left ventricle geometry and function: A 2-sample Mendelian randomization study.

ABSTRACT: Studies have shown that some inflammatory markers can predict the risk of cardiovascular disease (CVD) and affect the structure and function of the heart. However, a causal relationship between inflammatory markers and the cardiac structure and function has not yet been established. Thus, we conducted a 2-sample Mendelian randomization (MR) study to explore the potential causal relationship between inflammatory markers and prognostically-related left ventricular (LV) parameters. Instrumental variables (IVs) for C-reactive protein (CRP), interleukin-6 (IL-6), and myeloperoxidase (MPO) levels were selected from the databases of large genome-wide association studies (GWAS). Summary statistics for LV parameters, including LV mass, ejection fraction, end-diastolic and systolic volumes, and the

SUBMITTER: Lai B 

PROVIDER: S-EPMC11245243 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature