Vacuolar H⁺-ATPase determines daughter cell fates through asymmetric segregation of the nucleosome remodeling and deacetylase complex.

ABSTRACT: Asymmetric cell divisions (ACDs) generate two daughter cells with identical genetic information but distinct cell fates through epigenetic mechanisms. However, the process of partitioning different epigenetic information into daughter cells remains unclear. Here, we demonstrate that the nucleosome remodeling and deacetylase (NuRD) complex is asymmetrically segregated into the surviving daughter cell rather than the apoptotic one during ACDs in Caenorhabditis elegans. The absence of NuRD triggers apoptosis via the EGL-1-CED-9-CED-4-CED-3 pathway, while an ectopic gain of NuRD enables apoptotic daughter cells to survive. We identify the vacuolar H⁺-adenosine triphosphatase (V-ATPase) complex as a crucial regulator of NuRD's asymmetric segregation. V-ATPase interacts with Nu

SUBMITTER: Xie Z 

PROVIDER: S-EPMC11245309 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature