Transcriptome Analysis of Left Versus Right Intrinsic Laryngeal Muscles Associated with Innervation.

ABSTRACT:

Objectives/hypothesis

Recurrent laryngeal nerve injury diagnosed as idiopathic or due to short-term surgery-related intubation exhibits a higher incidence of left-sided paralysis. While this is often attributed to nerve length, it is hypothesized there are asymmetric differences in the expression of genes related to neuromuscular function that may impact reinnervation and contribute to this laterality phenomenon. To test this hypothesis, this study analyzes the transcriptome profiles of the intrinsic laryngeal muscles (ILMs), comparing gene expression in the left versus right, with particular attention to genetic pathways associated with neuromuscular function.

Study design

Laboratory experiment.

Methods

RNA was extracted from the left and right sides of the rat poste

SUBMITTER: Kemfack AM 

PROVIDER: S-EPMC11245368 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature