A hidden proteome encoded by circRNAs in human placentas: Implications for uncovering preeclampsia pathogenesis.

ABSTRACT:

Background

CircRNA-encoded proteins (CEPs) are emerging as new players in health and disease, and function as baits for the common partners of their cognate linear-spliced RNA encoded proteins (LEPs). However, their prevalence across human tissues and biological roles remain largely unexplored. The placenta is an ideal model for identifying CEPs due to its considerable protein diversity that is required to sustain fetal development during pregnancy. The aim of this study was to evaluate circRNA translation in the human placenta, and the potential roles of the CEPs in placental development and dysfunction.

Methods

Multiomics approaches, including RNA sequencing, ribosome profiling, and LC-MS/MS analysis, were utilised to identify novel translational events of circRNAs in huma

SUBMITTER: Zhao H 

PROVIDER: S-EPMC11245404 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature