Association of triglyceride glucose-body mass index with Alzheimer's disease pathology, cognition and brain structure in non-demented people.

ABSTRACT: The relationship between the triglyceride glucose-body mass index (TyG-BMI) index and Alzheimer's disease (AD) pathology, cognition, and brain structure remains unclear. This study aimed to investigate these associations, focusing on cerebrospinal fluid (CSF) biomarkers, cognitive measures, and brain imaging data. Eight hundred and fifty-five non-demented participants were included. Linear regression was used to explore associations between the TyG-BMI index and AD pathology, cognition, and brain structure. The association between the TyG-BMI index and AD risk was assessed using Kaplan-Meier and Cox proportional hazards models. Longitudinal relationships were assessed using linear mixed-effects models. Mediation analyses were conducted to examine AD pathology's potential mediating role bet

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC11245502 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature