Dataset Information

Small non-coding RNA transcriptomic profiling in adult and fetal human brain.

ABSTRACT: Small non-coding RNAs (sncRNAs) make up ~1% of the transcriptome; nevertheless, they play significant roles in regulating cellular processes. Given the complexity of the central nervous system, sncRNAs likely hold particular importance in the human brain. In this study, we provide sncRNA transcriptomic profiles in a range of adult and prenatal brain regions, with a focus on piRNAs, due to their underexplored expression in somatic cells and tissue-specific nature. Using the WIND workflow, which combines two detection methods, we found 1333 (731 miRNAs, 249 piRNAs, 285 snoRNAs, and 68 other sncRNAs) and 1445 unique sncRNAs (770 miRNAs, 307 piRNAs, 289 snoRNAs, and 79 other sncRNAs) in developing and adult brains, respectively. Significant variations were found upon comparison of fetal and adult brain groups, with 82 miRNAs, 17 piRNAs, and 70 snoRNAs enriched in fetal brains and 22 miRNAs, 11 piRNAs in adult brains. This dataset represents a valuable resource for exploring the sncRNA roles in brain function, their involvement in neurological diseases, and the molecular mechanisms behind brain region interactions.

SUBMITTER: Smal M

PROVIDER: S-EPMC11245507 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature

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Small non-coding RNA transcriptomic profiling in adult and fetal human brain.

Smal Marharyta M Memoli Domenico D Alexandrova Elena E Di Rosa Domenico D D'Agostino Ylenia Y Russo Fabio F Giurato Giorgio G Nassa Giovanni G Tarallo Roberta R Weisz Alessandro A Rizzo Francesca F

Scientific data 20240712 1

Small non-coding RNAs (sncRNAs) make up ~1% of the transcriptome; nevertheless, they play significant roles in regulating cellular processes. Given the complexity of the central nervous system, sncRNAs likely hold particular importance in the human brain. In this study, we provide sncRNA transcriptomic profiles in a range of adult and prenatal brain regions, with a focus on piRNAs, due to their underexplored expression in somatic cells and tissue-specific nature. Using the WIND workflow, which c ...[more]

PMID: 38997254

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Dataset Information

Small non-coding RNA transcriptomic profiling in adult and fetal human brain.

Publications

Small non-coding RNA transcriptomic profiling in adult and fetal human brain.

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