Temperature sensitivity of bat antibodies links metabolic state of bats with antigen-recognition diversity.

ABSTRACT: The bat immune system features multiple unique properties such as dampened inflammatory responses and increased tissue protection, explaining their long lifespan and tolerance to viral infections. Here, we demonstrated that body temperature fluctuations corresponding to different physiological states in bats exert a large impact on their antibody repertoires. At elevated temperatures typical for flight, IgG from the bat species Myotis myotis and Nyctalus noctula show elevated antigen binding strength and diversity, recognizing both pathogen-derived antigens and autoantigens. The opposite is observed at temperatures reflecting inactive physiological states. IgG antibodies of human and other mammals, or antibodies of birds do not appear to behave in a similar way. Importantly, diversificatio

SUBMITTER: Toshkova N 

PROVIDER: S-EPMC11245544 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature