Characterization of tumor evolution by functional clonality and phylogenetics in hepatocellular carcinoma.

ABSTRACT: Hepatocellular carcinoma (HCC) is a molecularly heterogeneous solid malignancy, and its fitness may be shaped by how its tumor cells evolve. However, ability to monitor tumor cell evolution is hampered by the presence of numerous passenger mutations that do not provide any biological consequences. Here we develop a strategy to determine the tumor clonality of three independent HCC cohorts of 524 patients with diverse etiologies and race/ethnicity by utilizing somatic mutations in cancer driver genes. We identify two main types of tumor evolution, i.e., linear, and non-linear models where non-linear type could be further divided into classes, which we call shallow branching and deep branching. We find that linear evolving HCC is less aggressive than other types. GTF2IRD2B mutations are enri

SUBMITTER: Kacar Z 

PROVIDER: S-EPMC11245610 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature