Causal association of genetically determined plasma metabolites with osteoarthritis: a two-sample Mendelian randomization study.

ABSTRACT:

Background

We aimed to elucidate the causal relationship between plasma metabolites and the vulnerability to Osteoarthritis (OA), encompassing both hip OA and knee OA.

Methods

We conducted a two-way two-sample Mendelian randomization (MR) analysis to investigate the association of 1,400 plasma metabolites with OA. The Inverse Variance Weighted (IVW) model served as the primary two-sample MR Analysis method, with supplementary analysis using the Weighted Median (WM) and MR Egger methods. To ensure the robustness of our findings, sensitivity analyses were performed, incorporating Cochran's Q test, MR-Egger intercept test, MR-PRESSO, and Leave-One-Out analyses. To validate the identified metabolites, we utilized the Steiger test and linkage disequilibrium score regression.

R

SUBMITTER: Fu Q 

PROVIDER: S-EPMC11245738 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature