Carbon-ion radiotherapy alone vs. standard dose photon radiation with carbon-ion radiotherapy boost for high-grade gliomas: a retrospective study.

ABSTRACT:

Background

This study aimed to compare the survival outcome and side effects in patients with primary high-grade glioma (HGG) who received carbon ion radiotherapy (CIRT) alone or as a boost strategy after photon radiation (photon + CIRT_boost).

Patients and methods

Thirty-four (34) patients with histologically confirmed HGG and received CIRT alone or Photon + CIRT_boost, with concurrent temozolomide between 2020.03-2023.08 in Wuwei Cancer Hospital & Institute, China were retrospectively reviewed. Overall survival (OS), progression-free survival (PFS), and acute and late toxicities were analyzed and compared.

Results

Eight WHO grade 3 and 26 grade 4 patients were included in the analysis. The median PFS in the CIRT alone and Photon + CIRT_boost<

SUBMITTER: Li X 

PROVIDER: S-EPMC11245814 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature