Molecular characterization of canine circovirus based on the Capsid gene in Thailand.

ABSTRACT:

Background

Canine circovirus (CanineCV) is a single-stranded circular DNA virus that infects domestic and wild canids in many countries. CanineCV is associated with gastroenteritis and diarrhea, respiratory disease, and generalized vasculitis leading to a fatal event. The Capsid protein (Cap) is a structural protein of the virus which has high genetic variability and plays a role in the canine immune response. In this study, we cloned the full-length CanineCV Capsid gene (Cap). In-silico analyses were used to explore the genomic and amino acid variability and natural selection acting on the Cap gene. The immune relevance for T-cell and B-cell epitopes was predicted by the immunoinformatic approach.

Results

According to the Cap gene, our results showed that CanineCV was separ

SUBMITTER: Dankaona W 

PROVIDER: S-EPMC11245861 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature