Targeting the senescence-related genes MAPK12 and FOS to alleviate osteoarthritis.

ABSTRACT:

Background

The mechanism by which chondrocyte senescence aggravate OA progression has not yet been well elucidated. The aim of this study was to investigate the chondrocyte senescence related gene biosignatures in OA, and to analyze on the underlying mechanisms of senescence in OA.

Materials and methods

We intersected osteoarthritis dataset GSE82107 from GEO database and senescence dataset from CellAge database of human senescence-associated genes based on genetic manipulations experiments plus gene expression profilin, and screened out 4 overlapping genes. The hub genes were verified in vitro and in human OA cartilage tissues by qRT-PCR. We further confirmed the function of mitogen-activated protein kinase 12 (MAPK12) and Fos proto-oncogene (FOS) in OA in vitro

SUBMITTER: Geng N 

PROVIDER: S-EPMC11245888 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature