Gut <i>Bifidobacterium longum</i> is associated with better native liver survival in patients with biliary atresia.

ABSTRACT:

Background & aims

The gut microbiome plays an important role in liver diseases, but its specific impact on biliary atresia (BA) remains to be explored. We aimed to investigate the microbial signature in the early life of patients with BA and to analyze its influence on long-term outcomes.

Methods

Fecal samples (n = 42) were collected from infants with BA before and after Kasai portoenterostomy (KPE). The stool microbiota was analyzed using 16S rRNA next-generation sequencing and compared with that of age-matched healthy controls (HCs). Shotgun metagenomic sequencing analysis was employed to confirm the bacterial composition in 10 fecal samples before KPE. The correlation of the microbiome signature with liver function and long-term outcomes was assessed.

Results

In th

SUBMITTER: Lee CS 

PROVIDER: S-EPMC11246047 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature