Establishment of human cerebral organoid systems to model early neural development and assess the central neurotoxicity of environmental toxins.

ABSTRACT: JOURNAL/nrgr/04.03/01300535-202501000-00032/figure1/v/2024-05-14T021156Z/r/image-tiff Human brain development is a complex process, and animal models often have significant limitations. To address this, researchers have developed pluripotent stem cell-derived three-dimensional structures, known as brain-like organoids, to more accurately model early human brain development and disease. To enable more consistent and intuitive reproduction of early brain development, in this study, we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid culture. This involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation, resulting i

SUBMITTER: Hu D 

PROVIDER: S-EPMC11246146 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature