Platelet inhibitor withdrawal and outcomes after coronary artery surgery: an individual patient data meta-analysis.

ABSTRACT:

Objectives

To evaluate the association between guideline-conforming as compared to shorter than recommended withdrawal period of P2Y12 receptor inhibitors prior to isolated on-pump coronary artery bypass grafting (CABG) and the incidence of severe bleeding and ischaemic events. Randomized controlled trials are lacking in this field.

Methods

We searched PUBMED, Embase and other suitable databases for studies including patients on P2Y12 receptor inhibitors undergoing isolated CABG and reporting bleeding and postoperative ischaemic events from 2013 to March 2024. The primary outcome was incidence of Bleeding Academic Research Consortium type 4 (BARC-4) bleeding defined as any of the following: perioperative intracranial bleeding, reoperation for bleeding, transfusion of ≥5 unit

SUBMITTER: Schoerghuber M 

PROVIDER: S-EPMC11246165 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature