Apple polysaccharide improves age-matched cognitive impairment and intestinal aging through microbiota-gut-brain axis.

ABSTRACT: The Apple polysaccharides (AP), extracted from the fruit of apple, has been used to treat multiple pathological diseases. In this study, we evaluated the effects of AP on cognitive impairment and intestinal aging in naturally aging mice. As a result, it was found that AP could improve spatial learning and memory impairment in aging mice through the Morris water maze experiment. Additionally, AP intervention can upregulate the expression of nerve growth factor (BDNF), postsynaptic marker (PSD95), and presynaptic marker (SYP) proteins. Moreover, AP can enhance total antioxidant capacity, reduce the level of pro-inflammatory cytokine, and inhibit the activation of the NF-κB signaling pathway, exerting anti-inflammatory and antioxidant functions. And the administration of AP restored intestina

SUBMITTER: Zhang W 

PROVIDER: S-EPMC11246462 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature