Aberrant brain network topology in youth with a familial risk for bipolar disorder: a task-based fMRI connectome study.

ABSTRACT:

Background

Youth with a family history of bipolar disorder (BD) may be at increased risk for mood disorders and for developing side effects after antidepressant exposure. The neurobiological basis of these risks remains poorly understood. We aimed to identify biomarkers underlying risk by characterizing abnormalities in the brain connectome of symptomatic youth at familial risk for BD.

Methods

Depressed and/or anxious youth (n = 119, age = 14.9 ± 1.6 years) with a family history of BD but no prior antidepressant exposure and typically developing controls (n = 57, age = 14.8 ± 1.7 years) received functional magnetic resonance imaging (fMRI) during an emotional continuous performance task. A generalized psychophysiological interaction (gPPI) analysis was performed to compare t

SUBMITTER: Pan N 

PROVIDER: S-EPMC11246494 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature