The mediating role of systemic inflammation and moderating role of racialization in disparities in incident dementia.

ABSTRACT:

Background

Exposure to systemic racism is linked to increased dementia burden. To assess systemic inflammation as a potential pathway linking exposure to racism and dementia disparities, we investigated the mediating role of C-reactive protein (CRP), a systemic inflammation marker, and the moderating role of the racialization process in incident dementia.

Methods

In the US Health and Retirement Study (n = 6,908), serum CRP was measured at baseline (2006, 2008 waves). Incident dementia was classified by cognitive tests over a six-year follow-up. Self-reported racialized categories were a proxy for exposure to the racialization process. We decomposed racialized disparities in dementia incidence (non-Hispanic Black and/or Hispanic vs. non-Hispanic white) into 1) the mediated ef

SUBMITTER: Higgins Tejera C 

PROVIDER: S-EPMC11246521 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature