Causal effects of denture wearing on epigenetic age acceleration and the mediating pathways: a mendelian randomization study.

ABSTRACT:

Background

The epigenetic-age acceleration (EAA) represents the difference between chronological age and epigenetic age, reflecting accelerated biological aging. Observational studies suggested that oral disorders may impact DNA methylation patterns and aging, but their causal relationship remains largely unexplored. This study aimed to investigate potential causal associations between dental traits and EAA, as well as to identify possible mediators.

Methods

Using summary statistics of genome-wide association studies of predominantly European ancestry, we conducted univariable and multivariable Mendelian randomization (MR) to estimate the overall and independent effects of ten dental traits (dentures, bleeding gums, painful gums, loose teeth, toothache, ulcers, periodontitis

SUBMITTER: Chen X 

PROVIDER: S-EPMC11246574 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature