Using pooled electronic health records data to conduct pharmacoepidemiology safety studies: Challenges and lessons learned.

ABSTRACT:

Purpose

We assessed the suitability of pooled electronic health record (EHR) data from clinical research networks (CRNs) of the patient-centered outcomes research network to conduct studies of the association between tumor necrosis factor inhibitors (TNFi) and infections.

Methods

EHR data from patients with one of seven autoimmune diseases were obtained from three CRNs and pooled. Person-level linkage of CRN data and Centers for Medicare and Medicaid Services (CMS) fee-for-service claims data was performed where possible. Using filled prescriptions from CMS claims data as the gold standard, we assessed the misclassification of EHR-based new (incident) user definitions. Among new users of TNFi, we assessed subsequent rates of hospitalized infection in EHR and CMS data.

Res

SUBMITTER: Beukelman T 

PROVIDER: S-EPMC11246592 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature