The histological spectrum and immunoprofile of head and neck NUT carcinoma: A multicentre series of 30 cases.

ABSTRACT:

Background and aim

Head and neck nuclear protein of testis carcinoma (HN-NUT) is a rare form of carcinoma diagnosed by NUT immunohistochemistry positivity and/or NUTM1 translocation. Although the prototype of HN-NUT is a primitive undifferentiated round cell tumour (URC) with immunopositivity for squamous markers, it is our observation that it may assume variant histology or immunoprofile.

Methods

We conducted a detailed clinicopathological review of a large retrospective cohort of 30 HN-NUT, aiming to expand its histological and immunohistochemical spectrum.

Results

The median age of patients with HN-NUT was 39 years (range = 17-86). It affected the sinonasal tract (43%), major salivary glands (20%), thyroid (13%), oral cavity (7%), larynx (7%), neck (7%) and nasopha

SUBMITTER: Viswanathan K 

PROVIDER: S-EPMC11246813 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature