Sex differences in spontaneous behavior and cognition in mice using an automated behavior monitoring system.

ABSTRACT: Isolation of sex differences as a key characteristic underlying neurobehavioral differentiation is an essential component of studies in neuroscience. The current study sought to address this concern by observing behavioral differences using an automated home cage system for neurobehavioral assessment, a method rapidly increasing in use due to advances in technology and advantages such as reduced handling stress and cross-lab variability. Sex differences in C57BL/6 mice arose for motor activity and circadian-linked behavior, with females being more active compared to males, and males having a stronger anticipatory increase in activity leading up to the onset of the light phase compared to females. These activity differences were observed not only across the lifespan, but also in different g

SUBMITTER: Bernstein BJ 

PROVIDER: S-EPMC11246821 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature