CD14+ Dendritic-Shaped Cells Functioning as Dendritic Cells in Rheumatoid Arthritis Synovial Tissues.

ABSTRACT:

Objective

We previously reported that CD14+ dendritic-shaped cells exhibit a dendritic morphology, engage in pseudo-emperipolesis with lymphocytes, and express CD90 in the perivascular areas of rheumatoid arthritis (RA) synovial tissues. However, it remains unclear whether these CD14^highCD90^{intermediate(int)} cells function as dendritic cells. In this study, we investigated the dendritic cell-differentiation potential of CD14^highCD90^int cells.

Methods

The localization and number of CD14^highCD90^int cells in RA synovial tissues and peripheral blood were examined. The dendritic cell-differentiation potential of CD14^highCD90^int cells was examined by measuring interleukin-6 and tumor necrosis f

SUBMITTER: Kurose R 

PROVIDER: S-EPMC11246827 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature