The levels of circulating cytokines and risk of neuromyelitis optica spectrum disorder: a Mendelian randomization study.

ABSTRACT:

Background

Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory autoimmune disease affecting the central nervous system (CNS). NMOSD pathogenesis involves systemic inflammation. However, a causal relationship between circulating cytokine levels and NMOSD remains unclear.

Methods

Mendelian randomization (MR) approaches were used to investigate the potential association between genetically determined circulating 19 inflammatory cytokines and 12 chemokines levels and the risk of developing NMOSD.

Results

After Bonferroni correction, the risk of aquaporin 4-antibody (AQP4-ab)-positive NMOSD was suggested to be causally associated with the circulating levels of three cytokines, including interleukin (IL)-4 [odds ratio (OR): 11.01, 95% confidence interval (CI):

SUBMITTER: Ma X 

PROVIDER: S-EPMC11246864 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature