CX3CL1 release during immunogenic apoptosis is associated with enhanced anti-tumour immunity.

ABSTRACT:

Introduction

Immunogenic cell death (ICD) has emerged as a novel option for cancer immunotherapy. The key determinants of ICD encompass antigenicity (the presence of antigens) and adjuvanticity, which involves the release of damage-associated molecular patterns (DAMPs) and various cytokines and chemokines. CX3CL1, also known as neurotactin or fractalkine, is a chemokine involved in cellular signalling and immune cell interactions. CX3CL1 has been denoted as a "find me" signal that stimulates chemotaxis of immune cells towards dying cells, facilitating efferocytosis and antigen presentation. However, in the context of ICD, it is uncertain whether CX3CL1 is an important mediator of the effects of ICD.

Methods

In this study, we investigated the intricate role of CX3CL1 in immun

SUBMITTER: Naessens F 

PROVIDER: S-EPMC11246865 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature