Blood immune cell profiling in adults with longstanding type 1 diabetes is associated with macrovascular complications.

ABSTRACT:

Aims/hypothesis

There is increasing evidence for heterogeneity in type 1 diabetes mellitus (T1D): not only the age of onset and disease progression rate differ, but also the risk of complications varies markedly. Consequently, the presence of different disease endotypes has been suggested. Impaired T and B cell responses have been established in newly diagnosed diabetes patients. We hypothesized that deciphering the immune cell profile in peripheral blood of adults with longstanding T1D may help to understand disease heterogeneity.

Methods

Adult patients with longstanding T1D and healthy controls (HC) were recruited, and their blood immune cell profile was determined using multicolour flow cytometry followed by a machine-learning based elastic-net (EN) classification model.

SUBMITTER: He X 

PROVIDER: S-EPMC11246869 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature