Association between serum uric acid and colorectal cancer risk in European population: a two-sample Mendelian randomization study.

ABSTRACT:

Objectives

This study aimed to explore the potential causal associations between serum uric acid (SUA) and the risk of colorectal cancer, colon cancer and rectal cancer.

Methods

Twenty-six SUA-related single nucleotide polymorphisms which were identified by a large meta-analysis of genome-wide association studies (GWASs) were used as instrumental variables in the two-sample Mendelian randomization (MR) study. Meta-analyses were used to synthesize the results of multiple GWASs which were extracted from the MRC Integrative Epidemiology Unit GWAS database for each type of cancer. The inverse variance weighted (IVW) method was used as the primary MR method to analyze the association between SUA and colorectal cancer risk. Several sensitivity analyses were performed to test the r

SUBMITTER: Zhou J 

PROVIDER: S-EPMC11246881 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature