Associations of modifiable factors with risk of irritable bowel syndrome.

ABSTRACT:

Background

Modifiable factors were found to be associated with the risk of irritable bowel syndrome (IBS) in observational studies, but whether these associations are causal is uncertain. We conducted a Mendelian randomization (MR) study to systematically explore the causal associations of modifiable factors with IBS.

Methods

Summary-level statistical data for IBS was obtained from a genome-wide association study (GWAS) meta-analysis of UK Biobank (40,548 cases and 293,220 controls) and the international collaborative Bellygenes initiative (12,852 cases and 139,981 controls). Genetic instruments associated with the exposures at the genome-wide significance (p < 5 × 10^-8) level were selected from previous GWASs. Mendelian randomization was performed using in

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11246901 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature