Causal association between phenylalanine and Parkinson's disease: a two-sample bidirectional mendelian randomization study.

ABSTRACT:

Background

Research findings indicate a putative indirect or latent association between phenylalanine (Phe) and Parkinson's disease (PD). In this study, we aimed to analyze the causal relationship between Phe and PD by two sample Mendelian randomization (MR) analysis.

Methods

In this study, the PD-related dataset and Phe-related dataset were downloaded from Integrative Epidemiology U1nit (IEU) Open Genome-Wide Association Study (GWAS) database. Four algorithms (MR Egger, maximum likelihood, inverse variance weighting (IVW) and unweighted regression) were used to perform MR analysis. The sensitivity analysis (heterogeneity test, horizontal pleiotropy test and Leave-One-Out (LOO) analysis) was used to assess the reliability of MR analyses.

Results

In the forward MR anal

SUBMITTER: Li S 

PROVIDER: S-EPMC11246959 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature